HemoBioTech’s Product and Technology
The Company’s proprietary production method consists of reacting pure bovine hemoglobin with three chemicals – o-adenosine 5’-triphosphate (o-ATP), o-adenosine, and reduced glutathione (GSH) – chemically modifying the hemoglobin to create beneficial activities and effect changes that control oxygen affinity and other biological activities.
A benefit of o-adenosine is that it counteracts the hemoglobin properties that cause the narrowing of blood vessels. It also reduces the potential of hemoglobin to cause inflammation.
Bovine Hemoglobin
The preference for bovine hemoglobin as an erythrocyte substitute, first proposed by Texas Tech researchers, was based on indications that bovine hemoglobin was more effective than human hemoglobin at transporting oxygen; that bovine erythrocytes were widely available; and that human and bovine diseases transmissible by blood could be avoided by collecting erythrocytes exclusively from select healthy cows. Bovine blood isolated and utilized for production of HemoTech™ is taken only from healthy cows, from a controlled herd.
Molecular Mechanisms
HemoTech™ has anti-inflammatory activity as a result of the presence of GSH and adenosine attached to it. This results in the lack of activated NF-Kappa B. NF-Kappa B is represented by the P50/p65 dimer in the Figure and is shown in the inactive form due to the presence of its inhibitor IKB. NF-Kappa B must be in the active form for the activation of inflammation. HemoTech™ prevents the inactivation of IKB, which results in the NF-Kappa B to remain inactive. It is further believed that HemoTech™ is vasodilatory as a result of the presence of adenosine, which activates the adenosine A2 receptor. This knowledge supports the properties of HemoTech™ observed during clinical studies.